transactivation domain meaning in English
激活区
Examples
- The comparative analysis of sequences indicated that the sequences of meq in different pathotypes are relatively conserved and the homology of the amino acid sequences is very high . the significant differences include two mutations in both mdv - 1 vaccine strains cvi988 / rispens and 814 strain : the deletion of a proline ( no . l93aa ) , and this mutation is just exactly located in a 15 - amino - acid ( eelcaqlcstppppi ) repeat sequence within the c - terminal transactivation domain of meq protein ; and a point mutation with a shift from alanine ( a ) of all virulent strains to serine ( s ) was occurred on the no . 71 aa
结果发现， mdv不同致病型的meq基因序列相对比较保守，它们相互间核苷酸和氨基酸序列的同源性均很高；但是，与所有七个致瘤性的mdv毒株相比，二个型弱毒疫苗cv1988 rispens株和814株均出现了两个特征性的突变：即第194位的p缺失性突变和第71位氨基酸由a变成了s的位点突变；缺失性突变恰恰位于meq基因中转录激活域内的一个多脯氨酸的重复序列( pppp )之中。 - The predicated amino acid sequences contain two conserved functional domains : a dna - binding domain ( hmg - box ) and a transactivation domain . the conserved motif of group b homology lies immediate adjacent to c - proximal region of the hmg - box . similar structure and identity of sox2 gene among mammals , birds , amphibians and reptiles suggest that sox2 gene have evolutionary conserved roles
进一步分析表明，已巴滩2编码的238个氨基酸多肤链含有两个保守的功能区域:位于n端的hmg盒区( 1一78aa )和位于c端的转录激活区( 131一236aa ) ，以及一个保守的特征性b亚族同源区域( 79一90aa )与hmg盒区的c端相连。